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If you've started noticing deeper creases around your mouth and nose when you smile — or even when your face is at rest — you're not alone. Smile lines, also known as nasolabial folds or laugh lines, are one of the most common cosmetic concerns we hear about at My Skin in St. Petersburg and Bradenton, Florida.
The good news? There are effective, minimally invasive treatments that can soften these lines and restore a more refreshed appearance. In this post, we'll break down everything you need to know about treating smile lines with Botox and other injectable options — including what actually works and why a personalized approach matters.

Smile lines are the folds or creases that run from the sides of your nose down to the corners of your mouth. They're a completely natural part of facial anatomy, but as we age, they can deepen significantly due to:
Loss of collagen and elastin in the skin
Decreased facial volume and fat pad shifting
Sun exposure and environmental damage
Repetitive facial movements over decades
Hormonal changes that accelerate skin aging
At My Skin, we understand that no two faces age the same way — which is why our provider, Leah Michel, APRN, FNP-BC, takes the time to evaluate your unique facial structure before recommending any treatment plan.
This is one of the most frequently asked questions we get — and the honest answer is: it depends on the cause and severity of your lines.
Botox (botulinum toxin) works by temporarily relaxing the muscles responsible for dynamic wrinkles — those caused by repetitive movement. It is highly effective for expression lines like forehead wrinkles, crow's feet, and frown lines between the brows.
For smile lines, the approach is a bit more nuanced:
If your smile lines are primarily caused by muscle movement — specifically the zygomaticus and levator labii muscles pulling on the skin repeatedly — strategic Botox placement can soften the crease and reduce how prominent the lines look when you smile. This technique is sometimes called a "lip flip" or perioral Botox and requires a highly skilled injector who understands facial anatomy.
Deeper nasolabial folds that are caused by volume loss — not just movement — respond better to dermal fillers than to Botox alone. As we age, the fat pads in our midface shift and diminish, creating a shadowing effect that makes smile lines look more pronounced. In these cases, Botox may not produce the improvement patients are hoping for.
That's why at My Skin, we take a comprehensive approach to facial rejuvenation rather than applying a one-size-fits-all solution.
Explore all of our cosmetic dermatology services in St. Pete and Bradenton to learn what's available.
For most patients with noticeable nasolabial folds, dermal fillers — particularly hyaluronic acid-based fillers — are the gold standard treatment. Fillers restore volume to the area, physically lifting the tissue and reducing the depth of the crease.
At My Skin, we offer a full range of injectable options:
Dermal fillers — hyaluronic acid fillers to restore midface volume and soften smile lines (learn more)
Lip fillers — for patients whose smile lines connect to a thinning lip border (learn more)
Sculptra — a collagen-stimulating biostimulator ideal for gradual, long-lasting volume restoration (learn more)
PRP Injections — harness your body's own growth factors to improve skin texture and quality (learn more)
Many patients benefit most from a combination approach — using Botox to address dynamic movement and fillers to address volume loss. Your treatment plan at My Skin will always be tailored specifically to your face, goals, and budget.
Every cosmetic treatment at My Skin begins with a thorough 30-minute consultation with Leah Michel. She will assess your facial structure, skin quality, and the root cause of your smile lines before recommending a course of treatment. There's no pressure and no cookie-cutter approach — just honest guidance.
Most injectable treatments are quick — often completed in 30 minutes or less. A topical numbing cream is applied beforehand for comfort. Botox takes 7–14 days to show full results, while filler results are visible almost immediately. There is minimal downtime; most patients return to normal activities the same day.
Botox: typically 3–4 months
Hyaluronic acid fillers: 9–12+ months depending on the product and area
Sculptra: gradual results that can last 2+ years
PRP: results build over 3–6 months with cumulative improvement
Injectable treatments work best when paired with a strong at-home skincare routine. We carry a curated selection of medical-grade skincare products at My Skin, chosen to complement your cosmetic treatments and maintain results longer.
Other treatments that can enhance your outcomes include:
Microneedling — stimulates collagen and improves skin texture around the mouth area
LED light therapy — reduce inflammation, support healing, and promote skin rejuvenation
Medical-grade skincare products — extend and enhance your results at home
Additionally, if hormonal changes are accelerating skin aging and volume loss, we also offer Bioidentical Hormone Replacement Therapy (BHRT). Declining estrogen levels play a significant role in collagen depletion and facial volume loss — so treating the root cause from the inside out can dramatically improve how cosmetic treatments perform.
Learn more about our Bioidentical Hormone Replacement Therapy for skin and wellness support.
The best candidates for smile line treatments are adults who:
Are bothered by deepening nasolabial folds or laugh lines
Want natural-looking results without surgery
Are in good overall health
Have realistic expectations about what injectables can achieve
Whether you're in your 30s noticing the first signs of smile line development, or in your 50s and 60s looking to refresh a more advanced crease, there are options available for every stage. The earlier you address these concerns, the more preventive your results can be.
Curious if you're a good candidate? Book a cosmetic consultation at our St. Pete or Bradenton office today.
Most patients describe Botox injections as a quick pinch. We use fine needles and apply a topical numbing cream beforehand to maximize comfort.
Yes! Many of our patients combine anti-wrinkle injections and dermal fillers in a single appointment for a more comprehensive refresh. Leah will recommend the right combination based on your individual goals.
Not with a skilled injector. At My Skin, our approach is always focused on enhancing your natural features — never creating an overdone look. Leah's background in cosmetic dermatology ensures that results look refreshed and natural.
Regular touch-up appointments, a consistent skincare routine using medical-grade products, sun protection, and healthy lifestyle habits all contribute to longer-lasting results. Ask about our Cosmetic Membership for savings on repeat treatments.
We have two convenient locations: 111 2nd Ave NE, Suite 1406, St. Petersburg, FL 33701 (Downtown St. Pete) and 4301 32nd St. W., Suite D2, Bradenton, FL 34277.
If smile lines have been making you feel self-conscious, you don't have to just accept it as part of aging. At My Skin in St. Petersburg and Bradenton, Florida, we offer personalized injectable treatments designed to restore a natural, refreshed look — tailored specifically to you.
To get started, request an appointment online, or call our St. Pete office at (727) 295-7223 or our Bradenton office at (941) 330-5805. We look forward to helping you love the skin you're in.
📍 St. Pete: (727) 295-7223 | Bradenton: (941) 330-5805
✉ appointments@myskinbyleah.com
Medical Disclaimer
The information provided in this blog post is intended for general educational purposes only and does not constitute medical advice, diagnosis, or treatment. Results from Botox, dermal fillers, or any other cosmetic treatment vary from person to person and cannot be guaranteed. Individual outcomes depend on factors including skin condition, age, anatomy, and the specific treatment plan recommended by your provider.
This content is not a substitute for professional medical advice. Always consult a qualified and licensed healthcare provider before beginning any cosmetic or medical treatment. If you have questions about whether a specific treatment is right for you, please schedule a consultation with Leah Michel, APRN, FNP-BC, or another licensed provider.
My Skin by Leah Michel is a cosmetic and medical dermatology practice located in St. Petersburg and Bradenton, Florida. All treatments are performed by or under the supervision of a licensed healthcare provider. Cosmetic treatments are elective and are not covered by insurance.
If you have any questions or concerns about your skin & would like to schedule an appointment at our St. Pete dermatology office or Brandenton dermatology office, please call us today!
111 2nd Ave NE., Suite 1406
St Petersburg, FL 33701
Plaza Tower- Downtown St Pete
Phone: (727) 295-7223
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